Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice
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چکیده
منابع مشابه
Phenotypic abnormalities in macrophages from leptin-deficient, obese mice.
Obesity is a complex syndrome that involves defective signaling by a number of different factors that regulate appetite and energy homeostasis. Treatment with exogenous leptin reverses hyperphagia and obesity in ob/ obmice, which have a mutation that causes leptin deficiency, proving the importance of this factor and its receptors in the obesity syndrome. Cells with leptin receptors have been i...
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ژورنال
عنوان ژورنال: Peptides
سال: 2007
ISSN: 0196-9781
DOI: 10.1016/j.peptides.2007.02.001